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J Acoust Soc Am. 2013 Feb;133(2):EL123-8. doi: 10.1121/1.4778375.

Laser enhanced high-intensity focused ultrasound thrombolysis: an in vitro study.

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1
KU Bioengineering Research Center, Department of Mechanical Engineering, University of Kansas, Lawrence, Kansas 66045, USA. hzhcui@ku.edu

Abstract

Laser-enhanced thrombolysis by high intensity focused ultrasound (HIFU) treatment was studied in vitro with bovine blood clots. To achieve laser-enhanced thrombolysis, laser light was employed to illuminate the sample concurrently with HIFU radiation, and ultrasound and laser parameters were optimized to achieve better thrombolysis efficiency. The results indicated that the thrombolysis efficiency increased when pulse length of HIFU wave, HIFU pressure, or laser fluence increases. Also, with the presence of laser, an enhanced effect of thrombolysis was observed.

PMID:
23363192
PMCID:
PMC3562328
DOI:
10.1121/1.4778375
[Indexed for MEDLINE]
Free PMC Article
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