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J Calif Dent Assoc. 2012 Dec;40(12):921-7.

Alphavbeta3 suppresses the RhoA-LIMK1 pathway in K1735 melanoma.

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University of California, Davis, USA.


Mucocutaneous melanoma has a five-year survival rate of less than 10 percent. The alphavbeta3 integrin promotes invasion, which requires actin reorganization by cofilin. The authors previously showed that cofilin and alphavbeta3 promote invasion. K1735 melanoma has several clones, each with different levels of alphavbeta3. The authors found that expression of alphavbeta3 suppresses activation of RhoA thus inhibiting LIMK1 phosphorylation of cofilin. This indicates that alphavbeta3 integrin suppresses the RhoA/ ROCK/LIMK1 pathway.

[Indexed for MEDLINE]

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