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Chembiochem. 2013 Feb 11;14(3):307-10. doi: 10.1002/cbic.201200712. Epub 2013 Jan 29.

Small-molecule-mediated axonal branching in Caenorhabditis elegans.

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1
Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, TX 78701, USA.

Abstract

An in vivo system for monitoring small-molecule-mediated neuronal branching has been developed by using C. elegans. Growth-promoting compounds can be detected by visual inspection of GFPlabeled cholinergic neurons, as axonal branching occurs following treatment with neurotrophic agents. Investigation of the structure-activity relationship of the neurotrophic natural product clovanemagnolol (1) led us to a comparable chemically edited derivative.

PMID:
23362121
PMCID:
PMC4470382
DOI:
10.1002/cbic.201200712
[Indexed for MEDLINE]
Free PMC Article
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