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Nat Rev Neurosci. 2013 Mar;14(3):161-76. doi: 10.1038/nrn3380. Epub 2013 Jan 30.

Axonal transport deficits and neurodegenerative diseases.

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Centre de Recherche de l'Institut du Cerveau et de la Moelle Épinière, INSERM UMR_S975, CNRS UMR7225, Université Pierre et Marie Curie, Hôpital de la Pitié-Salpêtrière, 47-83 boulevard de l'Hôpital, 75013 Paris, France.


The intracellular transport of organelles along an axon is crucial for the maintenance and function of a neuron. Anterograde axonal transport has a role in supplying proteins and lipids to the distal synapse and mitochondria for local energy requirements, whereas retrograde transport is involved in the clearance of misfolded and aggregated proteins from the axon and the intracellular transport of distal trophic signals to the soma. Axonal transport can be affected by alterations to various components of the transport machinery. Here, we review the current state of knowledge about axonal transport defects that might contribute to the pathogenesis of particular neurodegenerative diseases.

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