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J Cancer Res Ther. 2012 Oct-Dec;8(4):549-54. doi: 10.4103/0973-1482.106534.

Cannabinoid receptor 2 is upregulated in melanoma.

Author information

1
Department of Dermatology, Chinese People's Liberation Army General Hospital, Beijing, China.

Abstract

AIMS:

To investigate the expression of CB 2 in normal skin, pigmented nevus, and malignant melanoma; analyze its relation with genesis; and development of malignant melanoma.

MATERIALS AND METHODS:

In our study, we detected the expression of CB 2 in 20 cases of melanoma, nevus tissue, and normal skin tissues, respectively, by using immunohistochemistry, in situ hybridization, and RT-PCR. Moreover, we investigated the localization and expression of CB 2 in human melanoma cell line A375 and human immortalized keratinocyte cell line HaCaT by using immunofluorescence and western blotting.

RESULTS:

Our data revealed that CB 2 is unregulated in melanoma.

CONCLUSIONS:

CB 2 plays a role in the development of melanoma.

PMID:
23361273
DOI:
10.4103/0973-1482.106534
[Indexed for MEDLINE]

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