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Org Lett. 2013 Feb 15;15(4):898-901. doi: 10.1021/ol4000394. Epub 2013 Jan 29.

Iron-catalyzed benzannulation reactions of 2-alkylbenzaldehydes and alkynes leading to naphthalene derivatives.

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  • 1School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, PR China. zhusf@scut.edu.cn

Abstract

An efficient and practical method for the synthesis of naphthalene derivatives via Fe(III)-catalyzed benzannulation of 2-(2-oxoethyl)-benzaldehydes and alkynes has been developed. The system holds the advantages of cheap catalysts, wide substrate scope, and mild reaction conditions.

PMID:
23360560
DOI:
10.1021/ol4000394
[PubMed]
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