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Mol Carcinog. 2014 Jun;53(6):421-31. doi: 10.1002/mc.21999. Epub 2013 Jan 28.

Vitamin D: metabolism, molecular mechanisms, and mutations to malignancies.

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1
School of Biomedical and Health Sciences, Victoria University, St Albans, Australia.

Abstract

The potential protective effects of vitamin D against cutaneous carcinogenesis are still poorly understood. The inhibition, by vitamin D, of various cancers in in vitro and in vivo models has triggered detailed investigation of vitamin D effects on neoplastic behavior. Recent studies highlight that such neoplastic features as the tumor microenvironment, angiogenesis, DNA mutagenesis, and apoptosis are all connected to vitamin D metabolic pathways. This review discusses these connections. Vitamin D modulation of the cell cycle, DNA repair and apoptosis via its receptors (VDRs) may have a suppressive effect on skin cancer as some studies suggest. The regulation of multiple tumor signaling pathways by vitamin D may have an implication in cutaneous carcinogenesis and tumor progression to malignancy.

KEYWORDS:

NMSC; angiogenesis; cancer; tumor; vitamin D

PMID:
23359295
DOI:
10.1002/mc.21999
[Indexed for MEDLINE]
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