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Am J Perinatol. 2013 Oct;30(9):781-6. doi: 10.1055/s-0032-1333405. Epub 2013 Jan 28.

Randomized controlled trial of the effect of 30% versus 80% fraction of inspired oxygen on cesarean delivery surgical site infection.

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Departments of Obstetrics and Gynecology, Wright State University and Miami Valley Hospital, Dayton, Ohio.



To determine if supplemental perioperative oxygen will reduce surgical site infection (SSI) following cesarean delivery.


This is a randomized, controlled trial evaluating SSI following either 30% or 80% fraction of inspired oxygen (FIO2) during and 2 hours after cesarean delivery. Anesthesia providers administered FIO2 via a high-flow oxygen blender. Subjects, surgeons, and wound evaluation teams were blinded. Serial wound evaluations were performed. Data were analyzed using logistic regression models, Fisher exact test, and t test.


In all, 179 women were randomized, and 160 subjects were included in the analysis. There were 12/83 (14.5%) SSIs in the control group versus 10/77 (13.0%) in the investigational group (p = 0.82). Caucasian race, increased body mass index, and longer operative time were identified as significant risk factors for infection (p = 0.026, odds ratio 0.283; p = 0.05, odds ratio = 1.058; p = 0.037, odds ratio = 1.038, respectively).


Perioperative oxygenation with 80% Fio2 is not effective in reducing SSI following cesarean delivery.

[Indexed for MEDLINE]

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