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Am J Trop Med Hyg. 2013 Mar;88(3):464-8. doi: 10.4269/ajtmh.12-0196. Epub 2013 Jan 28.

Estimation of the impact of a Japanese encephalitis immunization program with live, attenuated SA 14-14-2 vaccine in Nepal.

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1
Child Health Division, Ministry of Health and Population, Kathmandu, Nepal. drshyam@hotmail.com

Abstract

Wider availability of the live, attenuated SA 14-14-2 Japanese encephalitis (JE) vaccine has facilitated introduction or expansion of immunization programs in many countries. However, information on their impact is limited. In 2006, Nepal launched a JE immunization program, and by 2009, mass campaigns had been implemented in 23 districts. To describe the impact, we analyzed surveillance data from 2004 to 2009 on laboratory-confirmed JE and clinical acute encephalitis syndrome (AES) cases. The post-campaign JE incidence rate of 1.3 per 100,000 population was 72% lower than expected if no campaigns had occurred, and an estimated 891 JE cases were prevented. In addition, AES incidence was 58% lower, with an estimated 2,787 AES cases prevented, suggesting that three times as many disease cases may have been prevented than indicated by the laboratory-confirmed JE cases alone. These results provide useful information on preventable JE disease burden and the potential value of JE immunization programs.

PMID:
23358643
PMCID:
PMC3592526
DOI:
10.4269/ajtmh.12-0196
[Indexed for MEDLINE]
Free PMC Article
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