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Cell Res. 2013 Apr;23(4):458-9. doi: 10.1038/cr.2013.14. Epub 2013 Jan 29.

Niche-less maintenance of HSCs by 2i.

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1
Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

Abstract

Maintenance of hematopoietic stem cells (HSCs) in vitro has been believed to be difficult due to a lack of complete understanding of HSC quiescence maintained by the niche. Recent evidence suggests that in vitro maintenance of human and mouse long-term HSCs (LT-HSCs) is possible through dual inhibition (2i) of both GSK-3 and mTOR in the absence of cytokines, serum, or feeder cells.

PMID:
23357848
PMCID:
PMC3616430
DOI:
10.1038/cr.2013.14
[Indexed for MEDLINE]
Free PMC Article
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