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Virology. 2013 Mar 30;438(1):1-4. doi: 10.1016/j.virol.2012.12.016. Epub 2013 Jan 26.

miR-132 enhances HIV-1 replication.

Author information

1
Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX 77030, USA.

Abstract

MicroRNAs upregulated during CD4(+) T cell activation may contribute to the increased efficiency of HIV-1 replication seen following perturbation of the resting state. We have found miR-132 to be highly upregulated following CD4(+) T cell activation, and show that miR-132 potentiates viral replication in the Jurkat CD4(+) T cell line. Knockdown of MeCP2, a previously identified target of miR-132, also increases HIV-1 replication. To the best of our knowledge, miR-132 is the first miRNA reported to enhance HIV-1 replication.

PMID:
23357732
PMCID:
PMC3594373
DOI:
10.1016/j.virol.2012.12.016
[Indexed for MEDLINE]
Free PMC Article

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