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Eur J Cell Biol. 2013 Mar;92(3):123-8. doi: 10.1016/j.ejcb.2012.11.004. Epub 2013 Jan 26.

The role of miRNA-29 family in cancer.

Author information

1
Department of Oncology, Tianjin Medical University, Tianjin, China. hutu120@sina.com

Abstract

The miRNA-29 family of microRNAs (miRNAs), including miR-29a, miR-29b and miR-29c, was recently reported to be aberrantly expressed in multiple cancers. Increasing evidence shows that the abnormal expression of miR-29 family is associated with tumorigenesis and cancer progression, making miR-29s a well-analyzed group of miRNAs in cancer research. Here, in this review we aim to provide an overview of the role of miR-29 family in the pathophysiologic changes of cancer cells and the epigenetic and immune regulation through the biological function of miR-29s.

PMID:
23357522
DOI:
10.1016/j.ejcb.2012.11.004
[Indexed for MEDLINE]

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