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Curr Opin Cell Biol. 2013 Apr;25(2):222-32. doi: 10.1016/j.ceb.2012.12.008. Epub 2013 Jan 25.

All's well that ends well: alternative polyadenylation and its implications for stem cell biology.

Author information

1
Paul F. Glenn Laboratories for the Biology of Aging, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.

Abstract

Stem cell quiescence, activation, and differentiation are governed by a complex network of molecular pathways. There has been a growing recognition that posttranscriptional modifications, such as alternative polyadenylation (APA) of transcripts, play an important role in regulating gene expression and function. Recent analyses of stem cell populations have suggested that APA controls stem cell fate and behavior. Here, we review recent developments that have shaped our understanding of the control of stem cell behavior by APA and we highlight promising areas for future investigation.

PMID:
23357469
PMCID:
PMC3615088
DOI:
10.1016/j.ceb.2012.12.008
[Indexed for MEDLINE]
Free PMC Article
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