Format

Send to

Choose Destination
See comment in PubMed Commons below
J Pharmacol Toxicol Methods. 2013 May-Jun;67(3):169-76. doi: 10.1016/j.vascn.2013.01.009. Epub 2013 Jan 26.

Reducing suffering in experimental autoimmune encephalomyelitis (EAE).

Author information

1
Seventeen Eighty Nine, 1st Floor, 21 High Street, Highworth, Swindon, SN6 7AG, United Kingdom.

Abstract

This report is based on discussions and submissions from an expert working group consisting of veterinarians, animal care staff and scientists with expert knowledge relevant to the field. It aims to facilitate the implementation of the Three Rs (replacement, reduction and refinement) in the use of animal models or procedures involving experimental autoimmune encephalomyelitis (EAE), an experimental model used in multiple sclerosis research. The emphasis is on refinement since this has the greatest potential for immediate implementation. Specific welfare issues are identified and discussed, and practical measures are proposed to reduce animal use and suffering. Some general issues for refinement are summarised to help achieve this, with more detail provided on a range of specific measures to reduce suffering.

PMID:
23357188
DOI:
10.1016/j.vascn.2013.01.009
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center