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Biochem Soc Trans. 2013 Feb 1;41(1):411-5. doi: 10.1042/BST20120276.

C/D box sRNA, CRISPR RNA and tRNA processing in an archaeon with a minimal fragmented genome.

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1
Max-Planck-Institute for Terrestrial Microbiology, Karl-von-Frisch Strasse 10, 35037 Marburg, Germany.

Abstract

The analysis of deep sequencing data allows for a genome-wide overview of all the small RNA molecules (the 'sRNome') that are present in a single organism. In the present paper, we review the processing of CRISPR (clustered regularly interspaced short palindromic repeats) RNA, C/D box sRNA (small non-coding RNA) and tRNA in Nanoarchaeum equitans. The minimal and fragmented genome of this tiny archaeon permits a sequencing depth that enables the identification of processing intermediates in the study of RNA processing pathways. These intermediates include circular C/D box sRNA molecules and tRNA half precursors.

PMID:
23356320
DOI:
10.1042/BST20120276
[Indexed for MEDLINE]
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