Format

Send to

Choose Destination
See comment in PubMed Commons below
Dis Model Mech. 2013 Mar;6(2):302-11. doi: 10.1242/dmm.010934. Epub 2013 Jan 25.

Highly impulsive rats: modelling an endophenotype to determine the neurobiological, genetic and environmental mechanisms of addiction.

Author information

1
Behavioural and Cognitive Neurosciences Institute and The Department of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK.

Abstract

Impulsivity describes the tendency of an individual to act prematurely without foresight and is associated with a number of neuropsychiatric co-morbidities, including drug addiction. As such, there is increasing interest in the neurobiological mechanisms of impulsivity, as well as the genetic and environmental influences that govern the expression of this behaviour. Tests used on rodent models of impulsivity share strong parallels with tasks used to assess this trait in humans, and studies in both suggest a crucial role of monoaminergic corticostriatal systems in the expression of this behavioural trait. Furthermore, rodent models have enabled investigation of the causal relationship between drug abuse and impulsivity. Here, we review the use of rodent models of impulsivity for investigating the mechanisms involved in this trait, and how these mechanisms could contribute to the pathogenesis of addiction.

PMID:
23355644
PMCID:
PMC3597013
DOI:
10.1242/dmm.010934
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center