Format

Send to

Choose Destination
Nat Neurosci. 2013 Feb;16(2):130-8. doi: 10.1038/nn.3304. Epub 2013 Jan 28.

Memory, navigation and theta rhythm in the hippocampal-entorhinal system.

Author information

1
NYU Neuroscience Institute and Center for Neural Sciences, New York University, New York, New York, USA. gyorgy.buzsaki@nyumc.org

Abstract

Theories on the functions of the hippocampal system are based largely on two fundamental discoveries: the amnestic consequences of removing the hippocampus and associated structures in the famous patient H.M. and the observation that spiking activity of hippocampal neurons is associated with the spatial position of the rat. In the footsteps of these discoveries, many attempts were made to reconcile these seemingly disparate functions. Here we propose that mechanisms of memory and planning have evolved from mechanisms of navigation in the physical world and hypothesize that the neuronal algorithms underlying navigation in real and mental space are fundamentally the same. We review experimental data in support of this hypothesis and discuss how specific firing patterns and oscillatory dynamics in the entorhinal cortex and hippocampus can support both navigation and memory.

PMID:
23354386
PMCID:
PMC4079500
DOI:
10.1038/nn.3304
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center