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Eur J Med Chem. 2013 Apr;62:148-57. doi: 10.1016/j.ejmech.2012.09.047. Epub 2012 Oct 16.

Synthesis of derivatives of methyl rosmarinate and their inhibitory activities against matrix metalloproteinase-1 (MMP-1).

Author information

1
Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.

Abstract

A series of MMP-1 inhibitors have been identified based upon a methyl rosmarinate scaffold using structure-based drug design methods. The best compound in the series showed an IC50 value of 0.4 μM. A docking study was conducted for compound (S)-10n in order to investigate its binding interactions with MMP-1. The structure-activity relationships (SAR) were also briefly discussed. Useful SAR was established which provides important guidelines for the design of future generations of potent inhibitors against MMP-1.

PMID:
23353736
DOI:
10.1016/j.ejmech.2012.09.047
[Indexed for MEDLINE]

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