Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Microbiol. 2013 Apr;16(2):156-62. doi: 10.1016/j.mib.2013.01.004. Epub 2013 Jan 24.

Determinants of specificity in two-component signal transduction.

Author information

1
Computational & Systems Biology Initiative, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.

Abstract

Maintaining the faithful flow of information through signal transduction pathways is critical to the survival and proliferation of organisms. This problem is particularly challenging as many signaling proteins are part of large, paralogous families that are highly similar at the sequence and structural levels, increasing the risk of unwanted cross-talk. To detect environmental signals and process information, bacteria rely heavily on two-component signaling systems comprised of sensor histidine kinases and their cognate response regulators. Although most species encode dozens of these signaling pathways, there is relatively little cross-talk, indicating that individual pathways are well insulated and highly specific. Here, we review the molecular mechanisms that enforce this specificity. Further, we highlight recent studies that have revealed how these mechanisms evolve to accommodate the introduction of new pathways by gene duplication.

PMID:
23352354
DOI:
10.1016/j.mib.2013.01.004
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center