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Breast. 2013 Oct;22(5):744-7. doi: 10.1016/j.breast.2012.12.012. Epub 2013 Jan 22.

Toxicity and cosmesis following partial breast irradiation consisting of 40 Gy in 10 daily fractions.

Author information

1
Department of Radiation Oncology, Centro di Riferimento Oncologico of Aviano, via F. Gallini 2, 33081 Aviano (PN), Italy. Electronic address: marcotrovo33@hotmail.com.

Abstract

PURPOSE:

To assess the toxicity and cosmetic results in breast cancer patients undergoing adjuvant partial breast irradiation (PBI) to a total dose of 40 Gy in 10 daily fractions (4 Gy/fraction).

METHODS AND MATERIALS:

Patients affected by early-stage breast cancer were enrolled in this phase II trial. Patients had to be 60 years old and treated with breast conservative surgery for early stage (pT1-T2 pN0-N1a) invasive ductal carcinoma.

RESULTS:

77 patients were enrolled. Median follow-up was 18 months. The proposed schedule was well tolerated. One patient reported Grade 3 pain at the site of irradiation. Four (5%) patients experience Grade 2 erythema. Late Grade 2 and 1 fibrosis was observed in 3 (4%) and 14 (18%) patients, respectively. Cosmesis was judged "good/excellent" and "poor" in 75 (97%) and in 2 (3%) patients, respectively.

CONCLUSIONS:

40 Gy in 10 daily fractions, 4 Gy/fraction, is a well tolerated regimen to deliver PBI.

KEYWORDS:

Breast cancer; Cosmesis; Hypofractionation; Partial breast irradiation; Toxicity

PMID:
23352319
DOI:
10.1016/j.breast.2012.12.012
[Indexed for MEDLINE]
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