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Med Sci (Paris). 2013 Jan;29(1):83-8. doi: 10.1051/medsci/2013291017. Epub 2013 Jan 25.

[Cancers of the upper aerodigestive tract associated with human papillomavirus].

[Article in French]

Author information

1
Service d'anatomie pathologique, hôpital européen Georges Pompidou, 20-40, rue Leblanc, 75015 Paris, France. cecile.badoual@egp.aphp.fr

Abstract

Carcinomas of the aerodigestive tract are most often secondary to alcohol and tobacco intoxication. However, it is shown that the oncogenic human papillomavirus (HPV) have an increasing role in the carcinogenesis of these cancers. Patients with HPV+ carcinoma are generally younger and not alcohol and tobacco users. These carcinomas are mainly localized in the oropharynx and in particular at the tonsil. HPV is found in 40 to 90 % of the cancers in the oropharynx, depending on the country. These HPV+ carcinomas have a better prognosis with better radio or chemosensitivity. To date, no change of treatment is recommended, however, several trials are underway. Preventive vaccination of boys is a real public health issue, especially since it is recommended in some countries. Moreover, a better understanding of the tumor microenvironment will ultimately offer therapeutic vaccination.

PMID:
23351698
DOI:
10.1051/medsci/2013291017
[Indexed for MEDLINE]
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