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Ann Endocrinol (Paris). 2013 Feb;74(1):45-8. doi: 10.1016/j.ando.2012.11.009. Epub 2013 Jan 23.

Association of the G-250A promoter polymorphism in the hepatic lipase gene with the risk of type 2 diabetes mellitus.

Author information

1
Center for Reproductive Medicine, First Affiliated Hospital of ZhengZhou University, 1, Jianshe Road, Zhengzhou, 450000, PR China.

Abstract

OBJECTIVE:

Variants in hepatic lipase (HL) gene which is a lipolytic enzyme involved in the metabolism of plasma lipoprotein and regulating lipid and lipoprotein metabolism are potential candidate genes for type 2 diabetes. Association of the polymorphisms in the promoter region of the HL gene (LIPC) to the plasma HDL-C concentration has been investigated. In this study, we investigated whether the G-250A polymorphism of LIPC is associated with type 2 diabetes in Chinese Han population.

SUBJECTS AND METHODS:

A total of 130 patients with type 2 diabetes and 133 healthy subjects as control were randomly selected from January 2008 to January 2011 in endocrine wards of Zhengzhou People's Hospital. The G-250A polymorphisms were studied by polymerase chain reaction and restriction fragment length polymorphism. A logistic regression analysis was performed to determine the association between the rare allele and type 2 diabetes mellitus.

RESULTS:

The frequency of the -250A allele was 0.297 in the T2DM group and 0.388 in the control group (P<0.05), with the difference remaining significant.

CONCLUSIONS:

Patients who are carrying of the -250A allele in the promoter of the LIPC gene are susceptible to type 2 diabetes mellitus in Chinese Han population.

PMID:
23351562
DOI:
10.1016/j.ando.2012.11.009
[Indexed for MEDLINE]

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