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Nanomedicine (Lond). 2013 Oct;8(10):1611-24. doi: 10.2217/nnm.12.168. Epub 2013 Jan 25.

Gadolinium(III)-gold nanorods for MRI and photoacoustic imaging dual-modality detection of macrophages in atherosclerotic inflammation.

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1
Ministry of Education Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China.

Abstract

AIM:

One of the features of high-risk atherosclerotic plaques is the preponderance of macrophages. Gadolinium(III)-gold nanorods (Gd(III)-GNRs) have been developed as a dual-modality probe for MRI and photoacoustic imaging (PAI) to trace macrophages for determining the degree of inflammation.

MATERIALS & METHODS:

Gd(III)-GNRs were utilized for MRI and PAI dual-modality detection of macrophages in living mice and ex vivo simulated macrophage-rich plaque.

RESULTS:

Gd(III)-GNRs were shown to be endocytosed by macrophages in vitro. Macrophages labeled with Gd(III)-GNRs were detected by both PAI and MRI. With Gd(III)-GNRs, it is possible to institute a multiscale complementary imaging protocol: MRI can screen to identify the location of the probe-phagocytosed macrophages, and intravascular PAI provides a subsequent precise morphology to quantify the infiltration area and invasion depth of macrophages in the arterial wall.

CONCLUSION:

This new dual-modality nanoparticle approach has promise for enabling quantitative detection of macrophages in atherosclerotic plaques.

PMID:
23351094
DOI:
10.2217/nnm.12.168
[Indexed for MEDLINE]
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