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Cancer Lett. 2013 May 10;332(1):94-101. doi: 10.1016/j.canlet.2013.01.023. Epub 2013 Jan 21.

miR-206 inhibits gastric cancer proliferation in part by repressing cyclinD2.

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1
State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, Shaanxi Province, China.

Abstract

In this study, we detected miR-206 expression in gastric cancer (GC) and further investigated its effects on GC cell growth in vitro and in vivo. miR-206 expression was found to be significantly decreased in 30 GC samples and GC cell lines by real time-PCR. Restoration of miR-206 reduced cell growth and colony forming ability in GC cells with G0/G1 cell cycle arrest. Further studies demonstrated that miR-206 could suppress GC cells proliferation at least partially through targeting the cyclinD2 (CCND2). Therefore, we provided evidence that miR-206 was a potential tumor suppressor and may be used as a therapeutic target for gastric cancer.

PMID:
23348698
DOI:
10.1016/j.canlet.2013.01.023
[Indexed for MEDLINE]
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