Format

Send to

Choose Destination
Ophthalmology. 2013 May;120(5):883-91. doi: 10.1016/j.ophtha.2012.10.025. Epub 2013 Jan 21.

Diagnosis of ocular surface lesions using ultra-high-resolution optical coherence tomography.

Author information

1
Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, Florida 33136, USA.

Abstract

PURPOSE:

To assess the use of ultra-high-resolution (UHR) optical coherence tomography (OCT) in the diagnosis of ocular surface lesions.

DESIGN:

Prospective, noncomparative, interventional case series.

PARTICIPANTS:

Fifty-four eyes of 53 consecutive patients with biopsy-proven ocular surface lesions: 8 primary acquired melanosis lesions, 5 amelanotic melanoma lesions, 2 nevi, 19 ocular surface squamous neoplasia lesions, 1 histiocytosis lesion, 6 conjunctival lymphoma lesions, 2 conjunctival amyloidosis lesions, and 11 pterygia lesions.

INTERVENTION:

Ultra-high-resolution OCT imaging of the ocular surface lesions.

MAIN OUTCOME MEASURES:

Clinical course and photographs, UHR OCT image, and histopathologic findings.

RESULTS:

Ultra-high-resolution OCT images of all examined ocular surface lesions showed close correlation with the obtained histopathologic specimens. When clinical differential diagnosis of ocular surface lesions was broad, UHR OCT images provided optical signs indicating a more specific diagnosis and management. In cases of amelanotic melanoma, conjunctival amyloidosis, and primary histiocytosis and in 1 case of ocular surface squamous neoplasia, UHR OCT was instrumental in guiding the diagnosis. In those cases, UHR OCT suggested that the presumed clinical diagnosis was incorrect and favored a diagnosis that later was confirmed by histopathologic examination.

CONCLUSIONS:

Correlations between UHR OCT and histopathologic findings confirm that UHR OCT is an adjunctive diagnostic method that can provide a noninvasive means to help guide diagnosis and management of ocular surface lesions.

FINANCIAL DISCLOSURE(S):

The author(s) have no proprietary or commercial interest in any materials discussed in this article.

PMID:
23347984
PMCID:
PMC3638067
DOI:
10.1016/j.ophtha.2012.10.025
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center