5-Iodo-2-aminoindan (5-IAI): chemistry, pharmacology, and toxicology of a research chemical producing MDMA-like effects

M Coppola; R Mondola

doi:10.1016/j.toxlet.2013.01.008

5-Iodo-2-aminoindan (5-IAI): chemistry, pharmacology, and toxicology of a research chemical producing MDMA-like effects

Toxicol Lett. 2013 Mar 27;218(1):24-9. doi: 10.1016/j.toxlet.2013.01.008. Epub 2013 Jan 21.

Authors

M Coppola¹, R Mondola

Affiliation

¹ Department of Addiction, ASL CN2, Viale Coppino 46, 12051 Alba (CN), Italy. coppolamail@alice.it

PMID: 23347877
DOI: 10.1016/j.toxlet.2013.01.008

Abstract

In 2010, an internet snapshot of EMCDDA anticipated the presence of 5-iodo-2-aminoindan (5-IAI) within the recreational drug market. In 2011, this compound, a psychoactive derivative of 2-aminoindane, was identified in recreational products sold in the United Kingdom. 5-IAI is a rigid analogue of p-iodoamphetamine producing MDMA-like effects. The aim of this paper is to summarize the clinical, pharmacological, and toxicological information about this new potential drug of abuse.

Publication types

Review

MeSH terms

3,4-Methylenedioxyamphetamine / analogs & derivatives*
3,4-Methylenedioxyamphetamine / chemistry
3,4-Methylenedioxyamphetamine / toxicity
Forensic Toxicology*
Humans
Illicit Drugs / chemistry
Illicit Drugs / toxicity*
Indans / chemistry
Indans / toxicity*
Molecular Structure
Substance Abuse Detection

Substances

Illicit Drugs
Indans
MMDA
3,4-Methylenedioxyamphetamine
5-iodo-2-aminoindan