Format

Send to

Choose Destination
Alcohol Clin Exp Res. 2013 Mar;37(3):490-7. doi: 10.1111/j.1530-0277.2012.01956.x. Epub 2013 Jan 24.

Early subjective response and acquired tolerance as predictors of alcohol use and related problems in a clinical sample.

Author information

1
Department of Psychology, Arizona State University, Tempe, Arizona 85287-1104, USA. wcorbin@asu.edu

Abstract

BACKGROUND:

Previous studies have demonstrated that a low subjective response (SR) to alcohol is a risk factor for alcohol use disorders (AUDs), and a recent study suggests that acquired tolerance can be differentiated from initial SR and is also significantly associated with drinking problems. Because the prior study of SR and tolerance focused on a sample of moderate drinkers, the goal of the current study was to examine relations between early SR, acquired tolerance, alcohol use, and alcohol-related problems in a sample of young adults with clinically significant alcohol problems.

METHODS:

The current study examined associations between early SR and acquired tolerance and both drinking behavior and alcohol-related problems within a sample of 113 heavy drinking young adults (66.1% male) volunteering for a clinical trial of naltrexone in combination with brief motivational counseling.

RESULTS:

Consistent with the 1 prior study examining simultaneous effects of early SR and tolerance, both early SR and acquired tolerance were positively associated with typical drinking behavior, although tolerance was a much stronger predictor within this clinical sample. In contrast to the prior study, early SR was inversely associated with risk for alcohol-related problems, and tolerance was not a significant predictor of problems.

CONCLUSIONS:

The results suggested that, controlling for weekly drinking, a low early SR protected against acute negative consequences within a sample of heavy drinkers who had acquired significant tolerance to alcohol effects. It is possible that this protective effect may eventually shift to a risk factor by allowing individuals with a low SR to persist in a pattern of hazardous drinking.

PMID:
23347236
PMCID:
PMC3586307
DOI:
10.1111/j.1530-0277.2012.01956.x
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center