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Skinmed. 2012 Nov-Dec;10(6):348-51.

Topical acne treatment with acetylcysteine: clinical and experimental effects.

Author information

1
Vitiligo Unit, Buenos Aires, Argentina. leopoldo.montes@hotmail.com

Abstract

Among the large variety of effects of acetylcysteine, several of them relate to cutaneous function in general and to sebaceous activity in particular. Due to the latter, a study was undertaken to investigate a possible effect of this substance in grade I acne. An analysis of the data from 99 patients in a double-blind study demonstrated that 5% acetylcysteine topical gel is significantly superior to placebo (P = .04) in reducing comedo counts. Comparable results were obtained in both sexes. This study indicates that acetylcysteine is an effective therapeutic option for the treatment of mild to moderate acne.

PMID:
23346662
[Indexed for MEDLINE]

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