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Sci Rep. 2013;3:1113. doi: 10.1038/srep01113. Epub 2013 Jan 23.

4-D photoacoustic tomography.

Author information

1
J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville , FL 32611, USA.

Abstract

Photoacoustic tomography (PAT) offers three-dimensional (3D) structural and functional imaging of living biological tissue with label-free, optical absorption contrast. These attributes lend PAT imaging to a wide variety of applications in clinical medicine and preclinical research. Despite advances in live animal imaging with PAT, there is still a need for 3D imaging at centimeter depths in real-time. We report the development of four dimensional (4D) PAT, which integrates time resolutions with 3D spatial resolution, obtained using spherical arrays of ultrasonic detectors. The 4D PAT technique generates motion pictures of imaged tissue, enabling real time tracking of dynamic physiological and pathological processes at hundred micrometer-millisecond resolutions. The 4D PAT technique is used here to image needle-based drug delivery and pharmacokinetics. We also use this technique to monitor 1) fast hemodynamic changes during inter-ictal epileptic seizures and 2) temperature variations during tumor thermal therapy.

PMID:
23346370
PMCID:
PMC3552346
DOI:
10.1038/srep01113
[Indexed for MEDLINE]
Free PMC Article

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