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Front Genet. 2013 Jan 22;3:311. doi: 10.3389/fgene.2012.00311. eCollection 2012.

MicroRNA dysregulation in multiple sclerosis.

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1
Department of Neurology and Neurosurgery, The Montreal Neurological Institute and Hospital, McGill University Health Centre, McGill University Montreal, QC, Canada ; Program in NeuroEngineering, McGill University Montreal, QC, Canada.

Erratum in

  • Front Genet. 2013;4:90.

Abstract

Multiple sclerosis (MS) is a chronic inflammatory disease characterized by central nervous system (CNS) demyelination and axonal degeneration. Although the cause of MS is still unknown, it is widely accepted that novel drug targets need to focus on both decreasing inflammation and promoting CNS repair. In MS and experimental autoimmune encephalomyelitis, non-coding small microRNAs (miRNAs) are dysregulated in the immune system and CNS. Since individual miRNAs are able to down-regulate multiple targeted mRNA transcripts, even minor changes in miRNA expression may lead to significant alterations in gene expression. Herein, we review miRNA signatures reported in CNS tissue and immune cells of MS patients and consider how altered miRNA expression may influence MS pathology.

KEYWORDS:

MS lesions; immune system; miRNA; multiple sclerosis; myelin

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