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Neurology. 2013 Feb 12;80(7):655-61. doi: 10.1212/WNL.0b013e318281cc83. Epub 2013 Jan 23.

The THRombolysis and STatins (THRaST) study.

Author information

1
SSO Stroke Unit, U.O. Neurologia d.O., DAI di Neuroscienze, Azienda Ospedaliera Universitaria Integrata, Italy. manuel_cappellari@libero.it

Abstract

OBJECTIVE:

To assess the impact on stroke outcome of statin use in the acute phase after IV thrombolysis.

METHODS:

Multicenter study on prospectively collected data of 2,072 stroke patients treated with IV thrombolysis. Outcome measures of efficacy were neurologic improvement (NIH Stroke Scale [NIHSS] ≤ 4 points from baseline or NIHSS = 0) and major neurologic improvement (NIHSS ≤ 8 points from baseline or NIHSS = 0) at 7 days and favorable (modified Rankin Scale [mRS] ≤ 2) and excellent functional outcome (mRS ≤ 1) at 3 months. Outcome measures of safety were 7-day neurologic deterioration (NIHSS ≥ 4 points from baseline or death), symptomatic intracerebral hemorrhage type 2 with NIHSS ≥ 4 points from baseline or death within 36 hours, and 3-month death.

RESULTS:

Adjusted multivariate analysis showed that statin use in the acute phase was associated with neurologic improvement (odds ratio [OR] 1.68, 95% confidence interval [CI] 1.26-2.25; p < 0.001), major neurologic improvement (OR 1.43, 95% CI 1.11-1.85; p = 0.006), favorable functional outcome (OR 1.63, 95% CI 1.18-2.26; p = 0.003), and a reduced risk of neurologic deterioration (OR: 0.31, 95% CI 0.19-0.53; p < 0.001) and death (OR 0.48, 95% CI 0.28-0.82; p = 0.007).

CONCLUSION:

Statin use in the acute phase of stroke after IV thrombolysis may positively influence short- and long-term outcome.

PMID:
23345634
PMCID:
PMC3590058
DOI:
10.1212/WNL.0b013e318281cc83
[Indexed for MEDLINE]
Free PMC Article
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