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J Virol. 2013 Apr;87(7):4091-6. doi: 10.1128/JVI.03235-12. Epub 2013 Jan 23.

Susceptibility of human iris stromal cells to herpes simplex virus 1 entry.

Author information

1
Department of Microbiology & Immunology, Midwestern University, Downers Grove, Illinois, USA.

Abstract

Ocular herpes simplex virus 1 (HSV-1) infection can lead to multiple complications, including iritis, an inflammation of the iris. Here, we use human iris stroma cells as a novel in vitro model to demonstrate HSV-1 entry and the inflammatory mediators that can damage the iris. The upregulated cytokines observed in this study provide a new understanding of the intrinsic immune mechanisms that can contribute to the onset of iritis.

PMID:
23345512
PMCID:
PMC3624200
DOI:
10.1128/JVI.03235-12
[Indexed for MEDLINE]
Free PMC Article

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