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Nat Rev Cancer. 2013 Feb;13(2):136-43. doi: 10.1038/nrc3446.

p63 steps into the limelight: crucial roles in the suppression of tumorigenesis and metastasis.

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1
Department of Biochemistry and Molecular Biology, Graduate School of Biomedical Sciences, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.

Abstract

The role of p63 in cancer has been an area of intense debate and controversy. Is TP63 (which encodes p63) a tumour suppressor gene or an oncogene? This debate is partly due to the complexity of the gene. There are several p63 isoforms - some with tumour suppressive functions and others with oncogenic functions. In this Opinion article, we focus on the recent advances in understanding p63 biology and its roles in cancer. In this regard, we discuss the role of p63 in multiple stem cell compartments, ageing, in the response to DNA damage and in DNA repair. Finally, we highlight the importance of understanding the interactions between all three p53 family members and the potential impact of this knowledge on cancer therapy and regenerative medicine.

PMID:
23344544
PMCID:
PMC4181578
DOI:
10.1038/nrc3446
[Indexed for MEDLINE]
Free PMC Article
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