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Nat Rev Cancer. 2013 Feb;13(2):97-110. doi: 10.1038/nrc3447.

Regulatory networks defining EMT during cancer initiation and progression.

Author information

1
Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, 9052 Zwijnaarde, Belgium.

Abstract

Epithelial to mesenchymal transition (EMT) is essential for driving plasticity during development, but is an unintentional behaviour of cells during cancer progression. The EMT-associated reprogramming of cells not only suggests that fundamental changes may occur to several regulatory networks but also that an intimate interplay exists between them. Disturbance of a controlled epithelial balance is triggered by altering several layers of regulation, including the transcriptional and translational machinery, expression of non-coding RNAs, alternative splicing and protein stability.

PMID:
23344542
DOI:
10.1038/nrc3447
[Indexed for MEDLINE]

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