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Molecules. 2012 Dec 21;18(1):128-39. doi: 10.3390/molecules18010128.

Cytotoxic and antioxidant compounds from the stem bark of Goniothalamus tapisoides Mat Salleh.

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1
Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia. rosalindkim@hotmail.com

Abstract

Eleven compounds:goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9-deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data. Goniothalamin (6) exhibited mild cytotoxic activity towards a colon cancer cell line (HT-29), with an IC(50)value of 64.17 ± 5.60 µM. Goniomicin B (2) give the highest antioxidant activity in the DPPH assay among all compounds tested, with an IC(50) of 0.207 µM.

PMID:
23344192
DOI:
10.3390/molecules18010128
[Indexed for MEDLINE]
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