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Biochem Biophys Res Commun. 1990 Apr 30;168(2):402-8.

cDNA cloning and characterization of ret activated in a human papillary thyroid carcinoma cell line.

Author information

1
Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan.

Abstract

We obtained activated ret cDNAs (retTPC) from a human papillary thyroid carcinoma cell line, TPC-1, and characterized its structure. The nucleotide sequence indicated that the recombination had occurred just upstream of the kinase domain of ret proto-oncogene and that the position, where the conserved sequence of ret proto-oncogene starts in retTPC transcripts, was exactly the same as that of ret-II which we have previously analyzed. Furthermore, a unique 13-glycine stretch, which is also present in a small subunit of the calcium dependent protease, calpain, was detected in the replaced sequence of retTPC. The aberrant tyrosine kinase activity induced by the rearrangement of ret proto-oncogene could be involved in the development of papillary thyroid carcinoma.

PMID:
2334411
DOI:
10.1016/0006-291x(90)92335-w
[Indexed for MEDLINE]

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