Format

Send to

Choose Destination
Int J Environ Res Public Health. 2013 Jan 14;10(1):278-94. doi: 10.3390/ijerph10010278.

Transfer of multidrug-resistant bacteria between intermingled ecological niches: the interface between humans, animals and the environment.

Author information

1
ICBAS - Abel Salazar Biomedical Sciences Institute, University of Porto, Porto, 4050-313, Portugal. pmcosta@icbas.up.pt

Abstract

The use of antimicrobial agents has been claimed to be the driving force for the emergence and spread of microbial resistance. However, several studies have reported the presence of multidrug-resistant bacteria in populations exposed to low levels of antimicrobial drugs or even never exposed. For many pathogens, especially those organisms for which asymptomatic colonization typically precedes infection (e.g., Enterococcus spp. and Escherichia coli), the selective effects of antimicrobial use can only be understood if we considerer all biological and environmental pathways which enable these bacteria, and the genes they carry, to spread between different biomes. This ecological framework provides an essential perspective for formulating antimicrobial use policies, precisely because it encompasses the root causes of these problems rather than merely their consequences.

PMID:
23343983
PMCID:
PMC3564142
DOI:
10.3390/ijerph10010278
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center