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Bioinformatics. 2013 Mar 15;29(6):807-9. doi: 10.1093/bioinformatics/btt038. Epub 2013 Jan 23.

SwarmDock: a server for flexible protein-protein docking.

Author information

1
Biomolecular Modelling Laboratory, Cancer Research UK London Research Institute, London WC2A 3LY, UK.

Abstract

Protein-protein interactions are central to almost all biological functions, and the atomic details of such interactions can yield insights into the mechanisms that underlie these functions. We present a web server that wraps and extends the SwarmDock flexible protein-protein docking algorithm. After uploading PDB files of the binding partners, the server generates low energy conformations and returns a ranked list of clustered docking poses and their corresponding structures. The user can perform full global docking, or focus on particular residues that are implicated in binding. The server is validated in the CAPRI blind docking experiment, against the most current docking benchmark, and against the ClusPro docking server, the highest performing server currently available.

PMID:
23343604
DOI:
10.1093/bioinformatics/btt038
[Indexed for MEDLINE]

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