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Toxicol Mech Methods. 2013 Jul;23(6):396-401. doi: 10.3109/15376516.2013.769655. Epub 2013 Apr 23.

The age-related change of glutathione antioxidant system in mice liver.

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The MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China.


Cellular glutathione (GSH) antioxidant system is an important defensive system of the body, which is crucial in the protection against oxidative stress-induced liver injury. The present study was designed to observe the difference of this system in the liver of mice with 1-month- and 12-month-old. Liver reduced GSH level was showed no difference between these two groups of mice. Next, the results showed that liver glutamate-cysteine ligase (GCL) activity was higher in mice of 1-month- than 12-month-old, while glutathione-S-transferase (GST) activity was higher in mice of 12-month- than 1-month-old. Further results showed that the higher activity of liver GCL in 1-month-old mice was due to the higher expression of catalytic subunit of GCL (GCLc) mRNA, while the higher activity of liver GST in 12-month-old mice might be due to the higher expression of GSTA1, GSTA2, GSTP1 and GSTP2 mRNA. Taken together, our results revealed the age-related change of liver GSH antioxidant system in mice, which may be helpful for elucidating some age-related liver injury or diseases.

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