Send to

Choose Destination
See comment in PubMed Commons below
J Geriatr Cardiol. 2012 Dec;9(4):379-88. doi: 10.3724/SP.J.1263.2012.08141.

Atrial fibrillation in the elderly: the potential contribution of reactive oxygen species.

Author information

Penn Cardiovascular Institute and Section of Cardiac Electrophysiology, University of Pennsylvania, Philadelphia, PA 19104, USA.


Atrial fibrillation (AF) is the most commonly encountered cardiac arrhythmia, and is a significant source of healthcare expenditures throughout the world. It is an arrhythmia with a very clearly defined predisposition for individuals of advanced age, and this fact has led to intense study of the mechanistic links between aging and AF. By promoting oxidative damage to multiple subcellular and cellular structures, reactive oxygen species (ROS) have been shown to induce the intra- and extra-cellular changes necessary to promote the pathogenesis of AF. In addition, the generation and accumulation of ROS have been intimately linked to the cellular processes which underlie aging. This review begins with an overview of AF pathophysiology, and introduces the critical structures which, when damaged, predispose an otherwise healthy atrium to AF. The available evidence that ROS can lead to damage of these critical structures is then reviewed. Finally, the evidence linking the process of aging to the pathogenesis of AF is discussed.


Aging; Arrhythmia; Atrial fibrillation; Cardiac; Free radicals; Oxidative stress; Redox

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Support Center