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J Korean Med Sci. 2013 Jan;28(1):152-5. doi: 10.3346/jkms.2013.28.1.152. Epub 2013 Jan 8.

An adult case of Fisher syndrome subsequent to Mycoplasma pneumoniae infection.

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  • 1Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.

Abstract

Reported herein is an adult case of Fisher syndrome (FS) that occurred as a complication during the course of community-acquired pneumonia caused by Mycoplasma pneumoniae. A 38-yr-old man who had been treated with antibiotics for serologically proven M. pneumoniae pneumonia presented with a sudden onset of diplopia, ataxic gait, and areflexia. A thorough evaluation including brain imaging, cerebrospinal fluid examination, a nerve conduction study, and detection of serum anti-ganglioside GQ1b antibody titers led to the diagnosis of FS. Antibiotic treatment of the underlying M. pneumoniae pneumonia was maintained without additional immunomodulatory agents. A complete and spontaneous resolution of neurologic abnormalities was observed within 1 month, accompanied by resolution of lung lesions.

KEYWORDS:

Anti-GQ1b Antibody; Fisher Syndrome; Mycoplasma pneumoniae

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