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J Korean Med Sci. 2013 Jan;28(1):67-73. doi: 10.3346/jkms.2013.28.1.67. Epub 2013 Jan 8.

Trends of mortality and cause of death among HIV-infected patients in Korea, 1990-2011.

Author information

1
Deparment of Internal Medicine, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea. mdssampak@yahoo.co.kr

Abstract

Although a decrease in acquired immunodeficiency syndrome (AIDS)-related mortality has been documented in highly active antiretroviral therapy (HAART) era, there are no published data comparing specific causes of death between pre-HAART and HAART era in Korea. Mortality and cause of death were analyzed in three treatment periods; pre-HAART (1990-1997), early-HAART (1998-2001), and late-HAART period (2002-2011). The patients were retrospectively classified according to the treatment period in which they were recruited. Although mortality rate per 100 person-year declined from 8.7 in pre-HAART to 4.9 in late-HAART period, the proportion of deaths within 3 months of initial visit to study hospital significantly increased from 15.9% in pre-HAART to 55.1% in late-HAART period (P < 0.001). Overall, 59% of deaths were attributable to AIDS-related conditions, and Pneumocystis pneumonia (PCP) was the most common cause of death (20.3%). The proportion of PCP as cause of death significantly increased from 8.7% in pre-HAART to 31.8% in late-HAART period (P < 0.001). Despite of significant improvement of survival, there was still a high risk of early death in patients presenting in HAART era, mainly due to late human immunodeficiency virus (HIV) diagnosis and late presentation to care.

KEYWORDS:

Antiretroviral Therapy; Cause of Death; HIV; Mortality

PMID:
23341714
PMCID:
PMC3546107
DOI:
10.3346/jkms.2013.28.1.67
[Indexed for MEDLINE]
Free PMC Article

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