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Biomarkers. 2013 Mar;18(2):103-15. doi: 10.3109/1354750X.2012.749302. Epub 2013 Jan 23.

Clinical and research markers of oxidative stress in chronic kidney disease.

Author information

1
Clinical Biochemistry Laboratory, Institute for Health and Social Science Research, Central Queensland University, Rockhampton, QLD, Australia.

Abstract

CONTEXT:

Kidney-related pathologies have increasing prevalence rates, produce a considerable financial burden, and are characterized by elevated levels of oxidative stress (OS).

OBJECTIVE:

This review examines relationships between chronic kidney disease (CKD) and markers of OS and antioxidant status (AS).

METHODS:

A systematic review of MEDLINE-indexed clinical trials, randomized controlled trials and comparative studies that examined OS and AS was performed.

RESULTS AND CONCLUSION:

Several markers emerged as well-suited indicators of OS and AS in CKD: malondialdehyde, F2-isoprostanes, lipid hydroperoxides, asymmetric dimethylarginine, 8-oxo-7,8-dihydro-2'-deoxyguanosine, protein carbonyls, advanced oxidation protein products and glutathione-related activity.

PMID:
23339563
DOI:
10.3109/1354750X.2012.749302
[Indexed for MEDLINE]

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