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Endokrynol Pol. 2012;63(6):463-9.

The role of orexin A in metabolic disturbances in patients with acromegaly.

Author information

1
Department of Endocrinology, Diabetology and Isotope Therapy, Medical University, 50-367 Wroclaw, Poland.

Abstract

INTRODUCTION:

It has been reported that orexins may play an important role in GH regulation. Orexins participate in the regulation of pituitary hormones secretion, food intake regulation, and the sleep-wake cycle. It has been suggested that a defect of orexin A synthesis could be responsible for disturbances in GH synthesis in patients with acromegaly, and consequently aggravate metabolic disturbances caused by high levels of IGF1.

THE AIM OF THIS STUDY:

THE AIM OF THIS STUDY was to assess orexin A levels in relation to the activity of the disease and the influence on metabolic profile in patients with acromegaly.

MATERIAL AND METHODS:

The subjects were 55 acromegalic patients divided into three main groups: a surgically cured acromegalic group (SCA); a well-controlled acromegalic group (WCA); an active acromegalic group (AA); and 29 healthy controls. In all subjects, blood samples were taken to assess the concentration of orexin A, lipids, glucose, insulin and hormones of the pituitary and peripheral glands.

RESULTS:

The concentration of orexin A was highest in the control group (CG) and lowest in the WCA group. The differences of orexin A concentration were statistically significant when each group of acromegalics were compared to the CG. There were no significant differences in orexin A concentration among the studied groups of patients with acromegaly. The metabolic disturbances were more often observed in the groups of acromegaly patients. In the AA group, orexin A concentrations correlated negatively with plasma lipids.

CONCLUSIONS:

The concentration of orexin A is reduced in acromegaly compared to healthy subjects.

PMID:
23339004
[Indexed for MEDLINE]
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