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Nat Rev Neurol. 2013 Feb;9(2):65-6. doi: 10.1038/nrneurol.2012.275. Epub 2013 Jan 22.

Dementia in 2012: Further insights into Alzheimer disease pathogenesis.

Author information

1
Center for Imaging of Neurodegenerative Diseases, Department of Radiology, San Francisco VA Medical Center/University of California San Francisco, 4150 Clement Street (114M), San Francisco CA, 94121 USA. michael.weiner@ucsf.edu

Abstract

In 2012, studies of autosomal dominant Alzheimer disease (AD), late-onset AD, and a rare genetic mutation of amyloid precursor protein provided support for the critical role of amyloid in AD pathogenesis. Increasing evidence implicated cell-to-cell transmission in the spread of tau and amyloid, highlighting novel targets for therapeutic intervention.

PMID:
23338285
DOI:
10.1038/nrneurol.2012.275
[Indexed for MEDLINE]
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