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Cancer Lett. 2013 May 1;331(2):167-73. doi: 10.1016/j.canlet.2012.12.026. Epub 2013 Jan 18.

Salmonella SL7207 application is the most effective DNA vaccine delivery method for successful tumor eradication in a murine model for neuroblastoma.

Author information

1
Laboratory of Pediatric Immunotherapy, Department of Experimental Obstetrics and Gynecology, Medical Faculty, Otto-von Guericke University of Magdeburg, Germany.

Abstract

Attenuated Salmonella is an approved oral life vaccine that is currently entering pre-clinical cancer vaccination studies as a promising DNA carrier. In a syngeneic mouse model for neuroblastoma, oral gavage of Salmonella typhimurium (SL7207) carrying recent generated survivin DNA vaccines induced a stronger cellular anti-NB immune response than gene gun application or injection of lentivirally transduced bone marrow-derived DCs. The level of Salmonella-associated side effects was not significant as indicated by unaffected survivin-mediated hematopoiesis and wound healing. We believe that our findings provide an important baseline to translate Salmonella-based DNA vaccination into a clinical application for neuroblastoma.

PMID:
23337288
DOI:
10.1016/j.canlet.2012.12.026
[Indexed for MEDLINE]

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