Format

Send to

Choose Destination
Curr Opin Immunol. 2013 Apr;25(2):238-45. doi: 10.1016/j.coi.2012.12.008. Epub 2013 Jan 18.

Materials based tumor immunotherapy vaccines.

Author information

1
School of Engineering and Applied Sciences, Harvard University, 29 Oxford Street, 319 Pierce Hall, Cambridge, MA 02138, USA.

Abstract

Immunotherapy is a promising approach for treating cancer. However, there are limitations inherent to current approaches which may be addressed by integrating them with biomaterial-based strategies. Material platforms have been fabricated to interact with immune cells through spatially controlled and temporally controlled delivery of immune modulators and to promote immune cell crosstalk. Particle vaccines have been developed to specifically target and deliver agents to organs, cells and subcellular compartments. These strategies have been shown to generate antigen-specific CTL responses and, in some cases, tumor regression. Therefore, collaboration between immunology and materials engineering is likely to result in the creation of strong vaccines to combat cancer in the future.

PMID:
23337254
PMCID:
PMC3644528
DOI:
10.1016/j.coi.2012.12.008
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center