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Neuropathol Appl Neurobiol. 2013 Aug;39(5):458-84. doi: 10.1111/nan.12020.

Review: the role of vitamin D in nervous system health and disease.

Author information

1
Nuffield Department of Clinical Neurosciences (Clinical Neurology), University of Oxford, Oxford, UK. gabriele.deluca@ndcn.ox.ac.uk

Abstract

Vitamin D and its metabolites have pleomorphic roles in both nervous system health and disease. Animal models have been paramount in contributing to our knowledge and understanding of the consequences of vitamin D deficiency on brain development and its implications for adult psychiatric and neurological diseases. The conflation of in vitro, ex vivo, and animal model data provide compelling evidence that vitamin D has a crucial role in proliferation, differentiation, neurotrophism, neuroprotection, neurotransmission, and neuroplasticity. Vitamin D exerts its biological function not only by influencing cellular processes directly, but also by influencing gene expression through vitamin D response elements. This review highlights the epidemiological, neuropathological, experimental and molecular genetic evidence implicating vitamin D as a candidate in influencing susceptibility to a number of psychiatric and neurological diseases. The strength of evidence varies for schizophrenia, autism, Parkinson's disease, amyotrophic lateral sclerosis, Alzheimer's disease, and is especially strong for multiple sclerosis.

KEYWORDS:

Parkinson's disease; amyotrophic lateral sclerosis; autism; multiple sclerosis; schizophrenia; vitamin D

PMID:
23336971
DOI:
10.1111/nan.12020
[Indexed for MEDLINE]

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