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Bioessays. 2013 Mar;35(3):242-52. doi: 10.1002/bies.201200108. Epub 2013 Jan 18.

Fate specification in the adult brain--lessons for eliciting neurogenesis from glial cells.

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Helmholtz Centre Munich German Research Centre for Environmental Health (GmbH), Institute for Stem Cell Research, Neuherberg/Munich, Germany.


In the adult mammalian brain, neurogenesis is restricted to few regions, while gliogenesis continues in a wide-spread manner. Here we discuss our knowledge of extrinsic and intrinsic factors regulating neuro- and gliogenesis in the adult brain and propose a model of fate specification identifying the states of easiest transition between glio- and neurogenesis, highlighting the unique mechanisms stabilising the neural stem cell state. The model also encompasses the fate alterations achieved by direct reprogramming, and hence addresses a novel avenue for repair, namely eliciting neurogenesis from glial cells outside the neurogenic niches.

[Indexed for MEDLINE]

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