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Eur Radiol. 2013 Jun;23(6):1643-9. doi: 10.1007/s00330-012-2745-2. Epub 2013 Jan 19.

Evaluation of liver fat in the presence of iron with MRI using T2* correction: a clinical approach.

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Department of Radiology, Innsbruck Medical University, Anichstraße 35, 6020 Innsbruck, Austria.

Erratum in

  • Eur Radiol. 2013 Jul;23(7):2049. Benjamin, Henninger [corrected to Henninger, Benjamin]; Christian, Kremser [corrected to Kremser, Christian]; Stefan, Rauch [corrected to Rauch, Stefan]; Robert, Eder [corrected to Eder, Robert]; Werner, Judmaier [corrected to Judmaier, Werner]; Heinz, Zoller [corrected to Zoller, Heinz]; Henrik, Michaely [corrected to Michaely, Henrik]; Michael, Schocke [corrected to Schocke, Michael].



To assess magnetic resonance imaging (MRI) with conventional chemical shift-based sequences with and without T2* correction for the evaluation of steatosis hepatitis (SH) in the presence of iron.


Thirty-one patients who underwent MRI and liver biopsy because of clinically suspected diffuse liver disease were retrospectively analysed. The signal intensity (SI) was calculated in co-localised regions of interest (ROIs) using conventional spoiled gradient-echo T1 FLASH in-phase and opposed-phase (IP/OP). T2* relaxation time was recorded in a fat-saturated multi-echo-gradient-echo sequence. The fat fraction (FF) was calculated with non-corrected and T2*-corrected SIs. Results were correlated with liver biopsy.


There was significant difference (P < 0.001) between uncorrected and T2* corrected FF in patients with SH and concomitant hepatic iron overload (HIO). Using 5 % as a threshold resulted in eight false negative results with uncorrected FF whereas T2* corrected FF lead to true positive results in 5/8 patients. ROC analysis calculated three threshold values (8.97 %, 5.3 % and 3.92 %) for T2* corrected FF with accuracy 84 %, sensitivity 83-91 % and specificity 63-88 %.


FF with T2* correction is accurate for the diagnosis of hepatic fat in the presence of HIO. Findings of our study suggest the use of IP/OP imaging in combination with T2* correction.


• Magnetic resonance helps quantify both iron and fat content within the liver • T2* correction helps to predict the correct diagnosis of steatosis hepatitis • "Fat fraction" from T2*-corrected chemical shift-based sequences accurately quantifies hepatic fat • "Fat fraction" without T2* correction underestimates hepatic fat with iron overload.

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